Zhang Chun-lan
2013
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Quality indicators
Journal
Chinese Journal of Veterinary Drug
Abstract
To evaluate safety of tilmicosin phosphate in the clinical use on the target animal swine,fifty 40-days old Jiang Qu Hai piglets were selected and administrated tilmicosin phosphate continuously with one fold dose,three fold dose,five fold dose and ten fold dose in drinking water for 21 days.The parameters of experimental piglets,such as blood routine,blood biochemistry,blood coagulation,urine routine,feed gain ratio and histopathological observation were tested before and after the experiment.The results showed that there was no obvious clinic symptom in experimental piglets.Except for the serum calcium and serum creatine kinase in the piglets of the ten fold dose group(800 mg/L),the tested parameters did not display the obvious differences compared with control group,indicating that tilmicosin phosphate was low toxic and it was safe to be administrated even with the ten fold dose(800 mg/L) on the target animal swine.