G. Ellames, Jennifer S. Gibson, J. Herbert
Nov 12, 2001
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Influential Citations
73
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Journal
Tetrahedron
Abstract
Abstract Exchange of protons for deuterons mediated by Crabtree's catalyst, 1, is directed efficiently by a functional group containing an sp2-hybridised nitrogen or oxygen atom; more electron-rich substrates are, in general, deuterated more efficiently. The electronic effects of substituents in the arene ring are critical only where the directing group is poor, in which case exchange is generally promoted by electron donating substituents, but the exchange is impeded by bulky meta-substituents.