Tingting Chen, C. Cai
Jan 10, 2016
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0
Influential Citations
8
Citations
Journal
Catalysis Communications
Abstract
Abstract A facile and efficient approach for the synthesis of N -substituted 3-oxoisoindoline-1-carbonitrile derivatives has been developed, with a Sc(OTf) 3 -catalyzed three-component Strecker/Lactamization cascade reaction involving methyl 2-formylbenzoate, TMSCN and amines in ethanol at room temperature. Good to excellent yields for a broad scope of amine substrates were achieved.