N. Kumar, A. Sharma, Reshu Garg
Mar 1, 2006
Citations
0
Influential Citations
4
Citations
Journal
ChemInform
Abstract
Synthesis of 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5H-benzo[a]phenothiazin-5-thione,12H-benzo[a] phenothiazin-5-ols, 5-acetoxy-12H-bcnzo[a] phenothiazines and 5-methoxy-12H-benzo[a]phenothiazines have been carried out from 6-(4-chloro-2-methoxy-5-methylanilino/2-methoxy-5-methylanilino)-9-chloro-5H-benzo[a] phenothiazin-5-ones; which have been synthesized by condensing zine mercaplide of 2-amino-5-chlorobenzenethiol and 2-(4-chloro-2-methoxy-5-methylanilio/2-methy-5-methylanilino)-3-cliloro-1,4-naphthoquinone. The ribofuranosides viz, N-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-6-(4-cliloro-2-methoxy-5-methanilino/2-methoxy -5-methylanilino)-9-chloro-5-acetoxy/5-methoxy-12H-benzo[a]phenothiazines have been synthesized by condensing synthesized heterocycles bases with (+)-β-D-ribofuranose-1-acetate -2,3,5-tribenzoale. Struclural assignments have been done on the basis of elemental analysis, IR, and 1 H NMR. All tlic synthesized compounds have been screened for their antimicrobial activity.