N. Desai, A. Dodiya, Atul H. Makwana
Aug 3, 2011
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Journal
Medicinal Chemistry Research
Abstract
As a part of systematic investigation of synthesis, characterization and antimicrobial screening of some novel 3-(2-(6-methyl-1H-benzo[d]imidazol-2-yl)phenyl)-2-(aryl)thiazolidin-4-ones (3a–l), have been synthesized from Schiff bases of N-arylidene-2-(6-methyl-1H-benzo[d]imidazol-2-yl)anilines, (2a–l). The Schiff bases (2a–l) were prepared by condensation of different aldehydes with 2-(6-methyl-1H-benzo[d]imidazol-2-yl)aniline (1). The compound (1) was obtained from 2-amino benzoic acid and 4-methylbenzene-1,2-diamine. All the synthesized compounds were screened for in vitro antibacterial and antifungal activities on Escherichiacoli, Staphylococcusaureus, Pseudomonasaeruginosa, Staphylococcuspyogenes, Candidaalbicans, Aspergillusniger, and Aspergillusclavatus. The structures of the compounds synthesized were elucidated by IR, 1H-NMR, 13C-NMR, and mass spectra.