N. Brennan, Xin Guo, L. Paquette
Jan 21, 2005
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0
Influential Citations
12
Citations
Journal
The Journal of organic chemistry
Abstract
A six-step conversion of oxirane 3 to oxetane 9 is reported. The synthetic route takes particular advantage of the acid-catalyzed ring opening of 3 to allyl alcohol 4 in a polar reaction medium and of the heightened capability of the OsO4.TMEDA complex to effect the efficient stereocontrolled dihydroxylation of this intermediate. The overall yield of the new sequence is 33%.