Gerardo X. Ortiz, Brett N. Hemric, Qiu Wang
Mar 10, 2017
Citations
0
Influential Citations
24
Citations
Journal
Organic letters
Abstract
Selective C-H amidation of 1H-indoles at the C3 position is reported as a direct entry to biologically important 3-aminoindoles. This transformation is achieved using novel N-[(benzenesulfonyl)oxy]amides as electrophilic nitrogen agents in the presence of ZnCl2. Interestingly, analogous reactions in the absence of ZnCl2 resulted in the formation of indole aminal products.