R. P. Elferink, J. de Haan, K. Lambert
Jun 1, 1989
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1
Influential Citations
56
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Journal
Hepatology
Abstract
Canalicular transport of bilirubin diglucuronide, dibromosulfophthalein and several glutathione conjugates is deficient in mutant TR− rats. In contrast, transport of cholyltaurine (taurocholate), a conjugated bile acid, is normal. Previous studies using normal rats have shown that C23 nor‐dihydroxy bile acids are conjugated with sulfate or glucuronide during hepatic transport in contrast to the natural C24 bile acids, which are amidated with glycine or taurine. Studies were performed to test the hypothesis that (a) in the TR− rat, nordeoxycholate would be conjugated with glucuronate or sulfate just as in the normal rat, and (b) that such conjugates would have defective biliary secretion. [C23‐14C]Nordeoxycholate was administered intravenously to bile fistula rats (TR− and normal), and the biliary recovery of metabolites was assessed by chromatography and mass spectrometry.