B. Pigott, K. Bartus, J. Garthwaite
Feb 20, 2013
Citations
3
Influential Citations
18
Citations
Journal
British Journal of Pharmacology
Abstract
Isoform‐selective inhibitors of NOS enzymes are desirable as research tools and for potential therapeutic purposes. Vinyl‐l‐N‐5‐(1‐imino‐3‐butenyl)‐l‐ornithine (l‐VNIO) and Nω‐propyl‐l‐arginine (NPA) purportedly have good selectivity for neuronal over endothelial NOS under cell‐free conditions, as does N‐[(3‐aminomethyl)benzyl]acetamidine (1400W), which is primarily an inducible NOS inhibitor. Although used in numerous investigations in vitro and in vivo, there have been surprisingly few tests of the potency and selectivity of these compounds in cells. This study addresses this deficiency and evaluates the activity of new and potentially better pyrrolidine‐based compounds.