Rebecca L. Grange, J. Ziogas, J. Angus
Sep 3, 2007
Citations
0
Influential Citations
27
Citations
Quality indicators
Journal
Tetrahedron Letters
Abstract
Abstract 2-Butyl-4-(methylseleno)-1-[[2′-(1 H -tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-1 H -imidazole-5-carboxylic acid ( 4 ) and 2-butyl-4-(phenylseleno)-1-[[2′-(1 H -tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-1 H -imidazole-5-carboxylic acid ( 5 ) have been prepared and tested for AT 1 receptor antagonist properties. Both compounds proved to be potent AT 1 receptor antagonists, with p K b estimates indicating that these selenides are very effective at blocking AT 1 receptor mediated responses.