Dongshan Zhang, Yong‐Ling Shi, W. Tian
Jun 1, 2015
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Journal
Chinese Journal of Chemistry
Abstract
We report the first semisynthesis of the natural insect antifeedant azedarachol. The synthesis features the employment of pregnanetriol, a degradative product of the resource natural product tigogenin, as the starting material, the symbiotic reaction involving the mutually-promoting elimination of toluene-sulfonate and deprotection of acetonide, and the controllable reactions between the C16-OH and the C20-OH in pregnane-16,20-diols.