C. Monteiro, N. Lourenço, C. Afonso
Apr 30, 2010
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Journal
Tetrahedron-asymmetry
Abstract
Abstract A two consecutive step procedure for the resolution-separation of secondary alcohols employing ethyl tetradecanoate in the presence of lipase allowed the enzymatic kinetic resolution of two target molecules, 1-phenylethanol and 6-methylhept-5-en-2-ol. ( S )-1-Phenylethanol was isolated in a yield of 47% with an ee of 94% and ( R )-1-phenylethanol in a yield of 51% with an ee of 95%. ( S )-6-Methylhept-5-en-2-ol was isolated in a yield 47% and an ee of 87% and ( R )-6-methylhept-5-en-2-ol in a yield 49% and an ee of 90%.