Xu Xiu-zhu
2003
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Journal
Journal of Hangzhou Institute of Applied Engineering
Abstract
Cetirizine hydrochloride, an antihistamine,is chiral whose (R)-( + )-enantiomer has no biological activity. In this paper,the enantioseparation of cetirizine hydrochloride was studied on CDMPC chiral stationary phase(CSP) . The influence of variation of alcohol modifier concentration and type in mobile phase was investigated respectively.