A. Brown, D. Ellis, D. A. Favor
Nov 15, 2013
Citations
0
Influential Citations
9
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A new series of 2-(benzyloxy)benzamides are presented that are potent functional antagonists of TRPM8 and possess improved LipE and LE compared to the original lead. They were discovered through a series of compound libraries and we present a powerful visualization method for the chemical space explored with each library. Remarkably this new series originated from the highest risk design strategy where compounds were synthesised with the least degree of similarity to the lead structure.