K. Kinnamon, E. Steck, D. S. Rane
Apr 1, 1979
Citations
0
Influential Citations
14
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
Antitrypanosomal activity for benzyltriphenylphosphonium salts is reported for the first time. Testing was conducted using Trypanosoma rhodesiense infected mice. Of 70 phosphorus-containing compounds tested, 21 were active. Sixteen of these active chemical species were benzyltriphenylphosphonium salts. Four were nonbenzyl triphenyl compounds. The remaining active drug was a benzyldiphenylphosphonium salt.