Takuya Takesue, Morifumi Fujita, T. Sugimura
Aug 26, 2014
Citations
0
Influential Citations
38
Citations
Journal
Organic letters
Abstract
A sequence of oxidation reactions of alkenamides with hypervalent iodine is described. Oxidation of ortho-alkenylbenzamide substrates selectively gave isochroman-1-imine products. The products underwent further oxidation in the presence of a Pd salt catalyst leading to regioselective C-H acetoxylation at the 8-position. A series of oxidations was applied to the crucial steps of asymmetric synthesis of 4-hydroxymellein derivatives.