Xiang Y. Yu, J. Finn, Jason M. Hill
Mar 8, 2004
Citations
1
Influential Citations
27
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
We have identified a series of spirocyclic furan and pyrrolidine inhibitors of Enterococcus faecalis and Staphylococcus aureus phenylalanyl-tRNA synthetases. The most potent analogue 1b showed IC50=5 nM (E. faecalis PheRS) and IC50=2 nM (S. aureus PheRS) with high selectivity over the human enzyme. The crystal X-ray structure of analogue 1b was determined.