Zhang Dong-hui, Cai Feng, Zhou Xiang-dong
Feb 1, 2005
Citations
0
Influential Citations
8
Citations
Journal
Chinese Journal of Chemistry
Abstract
A short and highly stereoselective synthesis of squalamine (1) was accomplished in 9 steps from easily available methyl chenodeoxycholanate (2). The advanced intermediate 7α,24R-dihydroxy-cholestan-3-one (9) was synthesized by using improved dehydrogenation of 4 followed by conjugate reduction and efficient asymmetric isopropylation of aldehyde 7 as key reactions.