S. Murahashi, T. Shiota
1987
Citations
1
Influential Citations
42
Citations
Journal
Tetrahedron Letters
Abstract
Catalytic oxidation of secondary amines with hydrogen peroxide followed by treatment with hydrogen cyanide gave α-cyanohydroxylamines (1). Hydrolysis of 1 gave N-hydroxyamino acids (2), which undergo catalytic hydrogenation to give amino acids (3). This is a simple, efficient and inexpensive method for synthesis of amino acids from amines.