Kazutaka Arai, Y. Chara, T. Iizumi
1983
Citations
0
Influential Citations
16
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 2-(6-Methoxy-2-naphthyl)propionic acid ( 4 ), dl-naproxen, was conveniently prepared by the regioselective reaction of alkyl 2-chloro-2-alkylthio-propionate ( 2 ) and 2-methoxynaphthalene ( 1 ) in good yield. This Friedel-Crafts reaction was found to be applicable to the other electron-rich aromatics.