C. Alden, R. L. Kanerva, R. Anderson
Jul 1, 1981
Citations
1
Influential Citations
23
Citations
Quality indicators
Journal
Veterinary Pathology
Abstract
Trisodium nitrilotriacetate monohydrate was fed to male weanling Charles River rats for 28 days. Clinical evidence of urinary tract toxicity included hydronephrosis and nephromegaly. Microscopically, severe renal injury was recognized specifically as convoluted tubular cytoplasmic vacuolation and pelvic epithelial erosion. Hyperplasia occurred as a sequela to these specific cytotoxic alterations.