F. Binder, Katrin Lemme, R. C. Preston
Jul 16, 2012
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0
Influential Citations
37
Citations
Journal
Angewandte Chemie
Abstract
Organized and released: Sialyl Lewis(x) (sLe(x)) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pre-organization allowing an array of directed hydrogen bonds, and the entropic benefit of the release of water molecules from the large binding interface to bulk water (see picture).