Ei, H. ., ua
2014
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Abstract
3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline ( I ), an important intermediate to synthesize pitavastatin calcium. It was prepared from ethyl 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxylate via reduction by KBH 4 /ZnCl 2 and then bromide by PBr 3 . The product was characterized by NMR and LC-MS. The crystal structure of compound I was investigated using X-ray diffraction and SHELXTL-97 software. The result indicated that compound I crystallized in the triclinic system, space group P-1 with a = 9.6150(19), b = 9.868 (2), c = 10.060(2) Å, V = 783.3 (4) Å 3 ; Z 2.