Y. Joshi, S. Saingar, Kavita Kavita
Aug 20, 2011
Citations
0
Influential Citations
12
Citations
Journal
Journal of The Korean Chemical Society
Abstract
The synthesis of biologically active 1H-1,4-diazepines 4a-d and 3H-1,5-benzodiazepines 5a-d in good yields, from the heterocyclization reaction of 2-(4-methylthio benzenesulfonyl)-1,3-dimethyl/1-methyl-3-phenyl/1,3-diphenyl/1-methyl-3- ethoxy propane-1,3-dione 3a-d with ethylenediamine (EDA) and o-phenylenediamine (o-PDA), respectively, in the presence of silica sulfuric acid (SSA) is described. The novel β-diketones/β-ketoesters 3a-d were synthesized by the condensation reac- tion of 4-methylthiobenzenesulfonyl chloride 1 with various β-diketones/β-ketoesters 2a-d. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral studies. The compounds 4a-d and 5a-d have been screened for antimicrobial, antifungal and anthelmintic activity.