E. Rosca
Jun 22, 2020
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Farmacia
Abstract
New 2-(4-(4-X-phenylsulfonyl)phenyl)-4-(3-bromo/3-bromo-4-methoxy-benzylidene)oxazol-5(4H)-ones have been synthesized by reaction of some 2-(4-(4-X-phenylsulfonyl)benzamido)acetic acids derivatives with 3-bromobenzaldehyde or 3-bromo-4methoxybenzaldehyde. The structures of the newly obtained heterocycles were elucidated by IR, H-NMR, C-NMR, mass spectra and elemental analysis. The cytotoxicity of the new oxazolones was evaluated using Artemia salina and Daphnia magna organisms and the in vitro antimicrobial activity was assessed on Gram-positive and Gram-negative bacterial and fungal strains.