René Martin, Célia Risacher, A. Barthel
Jul 1, 2014
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0
Influential Citations
16
Citations
Journal
European Journal of Organic Chemistry
Abstract
The pentahalogenated 2-arylpyrrole-type alkaloids pentabromopseudilin and pentachloropseudilin represent a new class of isoform-specific allosteric inhibitors of myosin ATPase. Herein, we describe an application of the silver(I)-catalyzed cycloisomerization of N-(homopropargyl)toluenesulfonamides to the total syntheses of these natural products and several non-natural analogues. Moreover, we examine the inhibitiory effect of pentahalogenated pseudilins on myosin ATPase activity.