G. Mahdavinia, Maryam Mirzazadeh, B. Notash
Jul 3, 2013
Citations
0
Influential Citations
20
Citations
Journal
Tetrahedron Letters
Abstract
Abstract An efficient regio- and chemoselective method for the synthesis of novel 3-amino-2′-oxospiro[benzo[c]pyrano[3,2-a]phenazine-1,3′-indoline]-2-carbonitrile/carboxylate derivatives has been developed via the one-pot, four-component domino coupling of 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, isatins, and malononitrile/cyanoacetic ester in the presence of DABCO under reflux conditions in excellent yields. The merit of this cascade formation of two C N bonds/Knoevenagel condensation/Michael addition/cyclization sequence is highlighted by its high atom-economy, excellent yields, efficiency of producing five new bonds (two C–N, two C–C, and one C–O), and one stereocenter in a single operation.