M. Divi, B. L. Rao, Aswatha Narayana Rao
Oct 24, 2013
Citations
0
Influential Citations
2
Citations
Journal
Organic Preparations and Procedures International
Abstract
Earlier, compound 2 had been prepared by heating a mixture of 1,1-cyclohexane –diacetic acid (1) and ammonium acetate in acetic anhydride.1 Acetic anhydride is a controlled chemical listed in the UN convention against illicit traffic in narcotic drugs and psychotropic substances.4 As a result of this convention, the availability of acetic anhydride is severely restricted and its use on an industrial scale is becoming difficult. Handley et al. had prepared 2 by heating an intimate mixture of 1 and urea at 170–190◦C, 5 the same method was adopted and modified in a recent PCT application.2 In this process, the solid mixture of 1 and urea was heated first to about 90◦C and the melt mix then slowly heated to about 140◦C, the molten mixture was stirred for about two hours until the evolution of gases had ceased. However, this process is not suitable for industrial scale because it is difficult