Srinivasarao Yaragorla, A. Pareek, Ravikrishna Dada
Aug 24, 2017
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24
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Journal
European Journal of Organic Chemistry
Abstract
Highly facile, single-step synthetic approach of 3-iodoquinolines is developed for the first time from readily available 2-aminobenzophenones and terminal alkynes. The reaction involves a nucleophilic addition of terminal alkynes to 2-aminobenzophenones followed by intramolecular regioselective iodocyclization (6-endo dig) to furnish 2,4-disubstituted, 3-iodoquinolines in high yields. In case of 2,4-diaryl substitution, the products were isolated without a column chromatography