Nobutaka Suzuki, Yasuji Izawa
1976
Citations
0
Influential Citations
5
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
2-Phenyl-2-thiazoline (4b) and its derivatives: [4-carboxylic acid (4c), 4-carboxylic acid methyl ester (4d), and 5,5-dimethyl-4-carboxylic acid (4e)], 2-(p-chlorophenyl)-2-thiazoline (4f) and its 4-carboxylic acid (4g), and 2-methyl-2-thiazoline (4h) were obtained by treating RCS2CH2CO2H [R=Phenyl (1b), p-chlorophenyl (Id), or methyl (1e)] or MeCS2Et (1f) with the corresponding 2-aminoethane thiols, i.e., cysteamine (6a), cysteine (6b), cysteine methy ester (6c), and/or penicillamine (6d). 4b was also obtained from PhCS2Et (1c) and 6a with a rate approximately equal to that from 1b and 6a. The attempted synthesis of 2-methyl-2-thiazoline-4-carboxylic acid (4i) using a similar method gave only N-acetylcysteine (7).