Simona S. Capomolla, Ngiap-Kie Lim, Haiming Zhang
Jul 1, 2015
Citations
0
Influential Citations
11
Citations
Journal
Organic letters
Abstract
An expedient single-step synthesis of 5,6,7,8-tetrahydroindolizines has been achieved via the annulation of commercially available 2-formylpiperidine hydrochloride and 1,3-dicarbonyl compounds in THF in the presence of pyrrolidine and 4 Å molecular sieves. A variety of β-ketoesters, ketones, and amides participated in this annulation chemistry, affording the desired 5,6,7,8-tetrahydroindolizines in moderate to good yields.