Baliram S. Hote,, Ajay S. Sawant, S. S. Sawant
Oct 19, 2020
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Influential Citations
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Journal
Polycyclic Aromatic Compounds
Abstract
Abstract A mild and highly efficient stereoselective reaction using silica supported bismuth(III) chloride (SiO2-BiCl3) has been successfully employed in the synthesis of 6-methyl-2-aryl-4, 5-dihydropyridazin-3(2H)-one derivatives (3a-o) with a variety of phenyl hydrazines (1a-o) bearing either electron withdrawing or donating functional groups and 4-pentynoic acid (2). The catalyzed reaction proceeded smoothly under room temperature in THF to give the corresponding 3a-o derivatives in good to excellent yields. The 3a-o derivatives have been characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis. The use of this approach allowed us to rapidly screen a selection of conditions and quickly confirm the viability of preparing the target 3a-o derivatives in short reaction times.