C. Chai, H. I. Chen, T. Yin
Dec 1, 1971
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Experimental neurology
Abstract
Abstract The effects of acetylstrophanthidin on body temperature were studied in unanesthetized monkeys. It was found that intravenous administration at 30–100 μg/kg produced a transient psychomotor stimulation followed by prolonged depression and decrease of body temperature of 0.7–2.7 C for periods of 6 to more than 20 hr. Administration of 5–20 μg acetylstrophanthidin into the lateral, third or fourth cerebral ventricle also produced the same psychomotor changes and decrease of body temperature of 1.2–3.8 C for 3–8 hr. In a single observation, administration of 50 μg into the lateral ventricle decreased the body temperature 8.8 C. Following the initial hypothermic response, there was a late increase of body temperature of 1.2–2.1 C for approximately 5 hr. Intracerebral administration of acetylstrophanthidin, 5 μg in 10 μl, to the preoptic area and the middle portion of the medulla oblongata produced a decrease of body temperature about 3 C for 3–8 hr, while the psychomotor changes were not apparent. Administration of acetylstrophanthidin into the rest of the brain stem was less or not at all effective. The data suggest that there exist in the preoptic area and medulla oblongata some neural elements which can respond to acetylstrophanthidin to lower the body temperature.