Yi Wang, D. Burton
Sep 1, 2007
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Influential Citations
8
Citations
Journal
Journal of Fluorine Chemistry
Abstract
A site-specific synthesis of 4-substituted-6-fluoro(carboalkoxyl)benzo[b]furans and benzo[b]thiophenes is described. The reactions of heterocyclic aromatic aldehydes with a Wittig reagent, followed by Sonogashira reaction with terminal alkynes, and subsequent base-catalyzed cyclization site-specifically provide 4-substituted-6-fluoro(carboalkoxyl)benzo[b]furans and benzo[b]thiophenes in good yields.