Koya Yamaguchi, Ryosuke Ueki, H. Yamada
Jul 8, 2011
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Journal
Analytical Methods
Abstract
[8-13C-7-15N]-labelled theophylline was synthesized and applied for in situ analysis using a 1H–{13C–15N} triple resonance NMR technique. The triple resonance analysis enabled selective detection of labelled theophylline in a mixture containing excess amino acids or crude mouse liver extract, where conventional 1H NMR analysis suffers from difficulty because of background signals.