J. J. Parlow, W. Naing, M. S. South
Nov 17, 1997
Citations
0
Influential Citations
54
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A specific example of a Sequestration Enabling Reagent (SER), tetrafluorophthalic anhydride, is used in the purification of solution-phase reactions involving amines with electrophiles. The SER is added to an incomplete reaction mixture containing product, amine, and electrophile. The SER covalently reacts with remaining amine, affording a derivatized amine with an artificially-imparted acid tag. This “tagged” amine is now sequesterable by the same CMR/R polyamine resin used to sequester the electrophile and both are easily removed from the reaction mixture affording pure product. © 1997 Elsevier Science Ltd.