N. Hamada, K. Kataoka, S. Sora
Nov 1, 2008
Citations
0
Influential Citations
12
Citations
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Abstract
This is the first study to demonstrate that the small-molecule Bcl-2 inhibitor HA14-1 renders human cervical cancer cells and their Bcl-2 overexpressing radioresistant counterparts, but not normal fibroblasts, more susceptible to heavy ions. Thus, Bcl-2 may be an attractive target for improving the efficacy of heavy-ion therapy.