M. Shimizu, Teruaki Shimazaki, Y. Kon
Feb 1, 2010
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Influential Citations
6
Citations
Journal
Heterocycles
Abstract
2-Mercaptopyridine-3-carboxylic acid reacts with methanol under acidic conditions to afford the corresponding S-methylated methyl ester, methyl 2-methylthiopyridine-2-carboxylate. Such S-methylation occurred for various N-containing heterocyclic thiols with acidic methanol. The reaction proceeded by the attack of mercapto groups on the conjugated acid of methanol. Therefore, the sulfur atom of pyridine-2-thiol was also methylated with acidic methyl ethers or methyl esters.