Yong-Jin Wu, C. Boissard, C. Greco
Jun 12, 2003
Citations
0
Influential Citations
51
Citations
Journal
Journal of medicinal chemistry
Abstract
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide (2) was synthesized as an orally bioavailable KCNQ2 potassium channel opener. In a rat model of migraine, 2 demonstrated significant oral activity in reducing the total number of cortical spreading depressions induced by potassium chloride.