Matthew L. Maddess, R. Carter
Apr 1, 2012
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Influential Citations
13
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Journal
Synthesis
Abstract
Pivalic acid is a useful medium to effect the direct SNAr displacement of 2-methylthio-4-pyrimidinones with a variety of anilines. Products are easily isolated in good to excellent yields, and following chlorination, provide an opportunity to rapidly query structure-activity relationships at the 4-position of functionalized pyrimidines.