Hou Lian-bin
2008
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Quality indicators
Journal
The Chinese Journal of Modern Applied Pharmacy
Abstract
OBJECTIVE To investigate the effect of sodium laurate on the permeability characteristics of rebamipide across the colonic membranes.METHODS The permeability(Papp) of rebamipide via rat intestinal membranes at concentration of 80 μmol·L-1 was evaluated by an in vitro diffusion chamber system after the membranes were isolated from the intestine in rat,with or without the co-administration of sodium laurate at different concentration.And the concentration of rebamipide in the receptor was determined by HPLC. RESULTS The permeability of rebamipide across the jejunal or ileal membranes was higher than that across the colonic membranes,and the transport of rebamipide in the ileal tissue from the mucosal to serosal direction was slightly greater than that from serosal to mucosal direction.Sodium laurate significantly increased the in vitro permeability of rebamipide across the colon membranes.And there exists a concentration-dependent effect of sodium laurate on the absorptive transport of rebamipide via colon.CONCLUSION There was a regional difference in the permeability of rabamipide across the jejunum,ileum and the colon in rat.Also,sodium laurate may be a useful absorption enhancer for the oral dosage forms.