S. Ercan, Nihal Öztürk, C. Celik-Ozenci
May 26, 2010
Citations
2
Influential Citations
24
Citations
Quality indicators
Journal
Toxicology and Industrial Health
Abstract
Sodium metabisulfite (Na 2S2O5) is used as an antioxidant and antimicrobial agent in a variety of drugs and functions as a preservative in many food preparations. This study was performed to elucidate the dose-dependent effects of sodium metabisulfite ingestion on rat gastric tissue apoptotic changes and lipid peroxidation. Forty male wistar rats, aged 3 months were used. They were randomly divided into four groups: control (C), the group treated with Na2S2O5 (10 mg/kg; S1), the group treated with Na2S2O5 (100 mg/kg; S2), the group treated with Na2S2O5 (260 mg/kg; S3). Na 2S2O5 was given by intragastric intubation for 35 days. In the S2 and S3 groups, malondialdehyde (MDA) levels increased markedly when compared with the control group. High doses of sulfite administration elevated number of apoptotic cells both in mucosa and submucosa layers of stomach in parallel with increased MDA levels. These results suggest that sodium metabisulfite increased lipid peroxidation and thus number of apoptotic cells on gastric tissue in dose-dependent manner.