Chengkou Liu, Zhao Yang, Yu Zeng
Jul 26, 2017
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Influential Citations
8
Citations
Journal
Organic chemistry frontiers
Abstract
A practical, economic and efficient sodium nitrite-promoted aerobic oxidative synthesis of polysubstitution imidazoles from aryl methyl ketones has been developed. (4 or 5)-Aryl-2-aroyl-imidazoles are generated in good yields under metal-free conditions and in a one step process, which show highly potent antiproliferative activity. Based on some control experiments, a possible mechanism was proposed. Moreover, other multisubstituted heterocyclic derivatives, such as 1,2,4-trisubstituted imidazoles, were prepared under the sodium nitrite-promoted aerobic oxidative conditions.