I. Tuzel
Oct 1, 1974
Citations
0
Influential Citations
57
Citations
Quality indicators
Journal
The Journal of Clinical Pharmacology
Abstract
SODIUM nitroprusside, a potent, rapidacting hypotensive agent when administered intravenously, has been known for many years hut has not been used in clinical practice to any great extent until recently. In the past several years, an increasing number of reports have appeared in the literature attesting to the drug’s safety and effectiveness in clinical practice. In the English language literature, there are reports of the use of the drug as a hypotensive agent in over 500 patients. It has been reported to be an effective and reliable hypotensive drug during hypertensive emergencies,4 for the production of controlled hypotensioii during anesthesia8-10’12’15-25 and renal angiography,1921 and in the treatment of patients with acute myocardial infarction26’27 and chronic heart failure.28 Intravenous sodium nitroprusside causes an immediate and potent hypotensivc response. Its hypotensive effects are evanescent, and continuous intravenous infusions of the drug are required to sustain the hypotensive response.