P. Galanaud, M. Crevon, M. Guenounou
Apr 1, 1980
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Influential Citations
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Quality indicators
Journal
Cellular immunology
Abstract
Abstract Sodium periodate treatment of human peripheral blood lymphocytes at submitogenic concentrations (10 −4 M ) completely inhibits their ability to mount a primary in vitro antibody response to trinitrophenyl-polyacrylamide beads. Transfer experiments show that (i) mitogenic concentrations (2 × 10 −3 M ) of sodium periodate induce suppressor cells to the in vitro antibody response: (ii) the generation of these suppressor cells is decreased but not abolished after mitomycin treatment, whereas that of Con A-induced suppressors is prevented; (iii) the periodate-induced suppression is present in the T-enriched fraction; and (iv). upon periodate treatment, T-depleted cells have a moderate but significant suppressive effect.