J. Burdon, V. McLoughlin
1964
Citations
0
Influential Citations
19
Citations
Journal
Tetrahedron
Abstract
Abstract Sodium has been used to promote the Claisen ester condensation of ethyl trifluoroacetate and ethyl acetate to give ethyl γγγ-trifluoroacetoacetate and then 1,1,1-trifluoroacetone by acidic hydrolysis. Sodium has also been used in the preparation of the α-methyl-, α-ethyl, and α-ethoxy-γγγ-trifluoroacetoacetate esters and of the 4,4,5,5,6,6,6-heptafluorobutyrylacetate ester from which the corresponding ketones have been prepared by hydrolysis. Some comments are made on the mechanism of Claisen condensations involving perfluoroesters and of the role of sodium in promoting them.