M. Schwarz, D. Tumelty, M. Gallop
Nov 12, 1998
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A solid-phase synthesis of polysubstituted 1,5-benzodiazepin-2-ones is described. Resin-bound 4-fluoro-3-nitrobenzoic acid was reacted with different β-amino acids, followed by nitro group reduction and formation of the seven-membered ring. Subsequent alkylations at N(5) and N(1) afforded the title compounds in high purities and yields.