Jinfang Zhang, J. Barker, B. Lou
Nov 26, 2001
Citations
0
Influential Citations
18
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A novel method for solid-phase synthesis of dihydroquinazoline derivatives is presented. Polymer-bound 4-bromomethyl-3-nitrobenzoate and the corresponding amide are utilized as versatile precursors that undergo nucleophilic displacement with amines followed by reduction and cyclocondensation reactions to afford structurally diverse dihydroquinazolines with excellent yield and purity.