J. Mayer, G. S. Lewis, C. McGee
Sep 10, 1998
Citations
0
Influential Citations
44
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A readily automated solid-phase approach to the synthesis of diverse benzimidazoles is described. The procedure utilizes polymer supported 4-fluoro-3-nitrobenzoic acid and a wide range of commercially available amines and aldehydes. The key heterocyclization step is achieved under mild conditions and was found to be general for a large number of diverse inputs.