Cheng Leng Lee, Y. Lam, Soo-Ying Lee
2001
Citations
1
Influential Citations
28
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Bis-(2-nitro-4-carboxyphenyl) disulfide was loaded on Wang resin and Rink amide resin. The nitro group was reduced to its amine with concomitant cleavage of the disulfide bond using SnCl 2 ·2H 2 O to afford 2 . Condensation of an aldehyde and nucleophilic attack on an α,β-unsaturated ketone, followed by TFA cleavage from the resin, gave benzothiazole 3 and 2,3-dihydro-[1,5]-benzothiazepine 4 , respectively.